IMSI (Intracytoplasmic Morphologically Selected Sperm Injection)

In recent years, along with the established method of intracytoplasmic sperm injection (ICSI), a new technique has been developed allowing us to make a better selection of sperm to be injected into the eggs. This technique is called Intracytoplasmic Morphologically selected Sperm Injection (IMSI) and is actually a sophisticated advancement to ICSI.

In IMSI, use is made of high power microscopes with special object lens allowing far larger magnification (approx. Χ6000) than those used in standard ICSI (Χ200-Χ400). These microscopes enable us to observe morphological changes in sperm that had been "invisible" until recently. As a result, we can select more accurately the optimal sperm to be injected and make best use of the eggs produced in the IVF process. Sperm morphology seems to be associated with the quality of the genetic material, hence with its capacity to fertilise a normal egg and create a healthy, implantable egg.

Indeed, according to international bibliography, comparing the results of IMSI cases versus ICSI cases, it is demonstrated that in the former case there is a higher rate of embryos reaching the blastocyst stage, an increased rate of clinical pregnancies and lower risk of miscarriage.

Therefore, this method seems to be particularly advisable for couples with a high percentage of atypical sperm forms (teratozoospermia), high level of DNA fragmentation in sperm cells or a history of early pregnancy losses / biochemical pregnancy miscarriages associated with low sperm quality.